A peptide antibiotic isolated from Paenibacillus polymyxa. It disrupts the cell membrane by binding to lipopolysaccharides in the outer membrane of Gram-negative bacteria. Used for infections caused by multidrug-resistant Gram-negative bacteria. Nephrotoxicity and neurotoxicity limit its use. Research-grade material for studies of antibacterial mechanisms, bacterial membrane permeability, and drug resistance.
Basic Information
- Product Name
- Polymyxin B
- Catalog No.
- P-32026
- CAS No.
- —
- Sequence
- S6MeC8-T[Dab][Dab][Dab][Dab][Dab][dF]L[Dab]T {cyclo=lactam:[Dab]3-T10}
- Molecular Formula
- C23H36N4O7
- Molecular Weight
- 2794.21
Peptide Depictor
10 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
S6MeC8-T[Dab][Dab][Dab][Dab][Dab][dF]L[Dab]T {cyclo=lactam:[Dab]3-T10}
Length
10.00
Molecular Weight
1202.75 Da
Monoisotopic Mass
1202.75 Da
Estimated Net Charge
0.000
pI
Not calculated
Hydrophobicity GRAVY
0.2400
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
0%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.03750————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02172————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7690————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.8231————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -7.439 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.843 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8491 | Model output only, not in-vivo half-life |