A peptide antibiotic structurally similar to polymyxin B, differing in that position 6 contains Leu instead of Phe. Active against Gram-negative bacteria and used for multidrug-resistant bacterial infections. One of the last-resort antibiotics. Research-grade material for studies of antimicrobial peptide mechanisms, bacterial resistance, and membrane-targeting antibiotics.
Basic Information
- Product Name
- Colistin (Polymyxin E)
- Catalog No.
- P-32027
- CAS No.
- —
- Sequence
- [Dab]T[Dab][Dab]LL[Dab][Dab]T
- Molecular Formula
- C20H38N4O7
- Molecular Weight
- 1161.37
Peptide Depictor
9 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
[Dab]T[Dab][Dab]LL[Dab][Dab]T
Length
9.000
Molecular Weight
946.59 Da
Monoisotopic Mass
946.59 Da
Estimated Net Charge
0.000
pI
6.010
Hydrophobicity GRAVY
0.6890
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
0%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.02609————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.2852————0.3892 | Fouling |
| Solubility | score threshold | 0.9860————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.5722————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.5378————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -14.13 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.857 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 1.442 | Model output only, not in-vivo half-life |