A hormone secreted by pancreatic alpha cells that counteracts the action of insulin, promoting hepatic glycogenolysis and gluconeogenesis and increasing blood glucose levels. Used for emergency treatment of severe hypoglycemia. Research-grade material is used in studies of blood glucose regulation, glucose metabolism, diabetes mechanisms, and pancreatic islet function.
Basic Information
- Product Name
- Glucagon (Human)
- Catalog No.
- P-32025
- CAS No.
- 16941-32-5
- Sequence
- H-HSQGTFTSDYSKYLDSRRAQDFVQWLMNT-OH
- Molecular Formula
- C153H225N43O49S
- Molecular Weight
- 3482.79
Peptide Depictor
29 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-HSQGTFTSDYSKYLDSRRAQDFVQWLMNT-OH
Length
29.00
Molecular Weight
3480.62 Da
Monoisotopic Mass
3480.62 Da
Estimated Net Charge
0.1000
pI
7.700
Hydrophobicity GRAVY
-0.9900
Physicochemical Properties
Basic Residue Ratio
10%
Acidic Residue Ratio
10%
Aromatic Residue Ratio
17%
Cys Count
0.000
Oxidation-Risk Residues
2.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.07149————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.01563————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7797————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.06979————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -13.77 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.862 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7984 | Model output only, not in-vivo half-life |