Endogenous μ-opioid receptor agonist, structurally similar to endomorphin-1 (Phe replacing Trp at position 3). It shows distinct distribution in the central nervous system and functional differences. Potent analgesic activity. Research-grade material for studies of opioid receptor subtypes, pain modulation, and endogenous analgesic systems.
Basic Information
- Product Name
- Endomorphin-2
- Catalog No.
- P-32052
- CAS No.
- 141801-26-5
- Sequence
- H-YPFF-NH2
- Molecular Formula
- C32H36N4O6
- Molecular Weight
- 571.68
Peptide Depictor
4 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-YPFF-NH2
Length
4.000
Molecular Weight
571.28 Da
Monoisotopic Mass
571.28 Da
Estimated Net Charge
0.000
pI
9.880
Hydrophobicity GRAVY
0.6750
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
75%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.7682————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.09085————0.3892 | Fouling |
| Solubility | score threshold | 0.9833————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8827————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.9842————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -6.291 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.849 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8552 | Model output only, not in-vivo half-life |