Endogenous opioid peptide with a pentapeptide structure. Agonist of δ and μ opioid receptors; involved in analgesia, reward, and mood regulation. Widely distributed in the central and peripheral nervous systems. Short half-life and rapidly degraded by peptidases. Research grade for studies of opioid receptors, pain, neuropeptides, and reward systems.
Basic Information
- Product Name
- Leu-Enkephalin
- Catalog No.
- P-32053
- CAS No.
- 58822-25-6
- Sequence
- H-YGGFL-OH
- Molecular Formula
- C28H37N5O7
- Molecular Weight
- 555.63
Peptide Depictor
5 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-YGGFL-OH
Length
5.000
Molecular Weight
555.27 Da
Monoisotopic Mass
555.27 Da
Estimated Net Charge
0.000
pI
5.940
Hydrophobicity GRAVY
0.9000
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
40%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.01434————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.1280————0.3892 | Fouling |
| Solubility | score threshold | 0.9860————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7578————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.2172————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -8.364 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.849 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8116 | Model output only, not in-vivo half-life |