Endogenous highly selective μ-opioid receptor agonist with a tetrapeptide structure. Exhibits potent analgesic activity and serves as an endogenous mediator of morphine-like analgesia. Shows higher selectivity for μ receptors than enkephalins. Research-grade material for studies of opioid receptors, pain mechanisms, endogenous analgesic systems, and drug addiction.
Basic Information
- Product Name
- Endomorphin-1
- Catalog No.
- P-32051
- CAS No.
- 189388-22-5
- Sequence
- H-YPWF-NH2
- Molecular Formula
- C34H37N5O6
- Molecular Weight
- 610.71
Peptide Depictor
4 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-YPWF-NH2
Length
4.000
Molecular Weight
610.29 Da
Monoisotopic Mass
610.29 Da
Estimated Net Charge
0.000
pI
9.880
Hydrophobicity GRAVY
-0.2500
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
75%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.7039————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.04983————0.3892 | Fouling |
| Solubility | score threshold | 0.9858————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8522————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.9486————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -6.517 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.855 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7734 | Model output only, not in-vivo half-life |