A tachykinin family neuropeptide and endogenous ligand of the NK1 receptor. It is involved in pain transmission, inflammation, emesis, and mood regulation, and transmits nociceptive signals in the dorsal horn of the spinal cord. Research-grade material for studies of pain mechanisms, neuroinflammation, the emetic reflex, and NK1 receptor biology.
Basic Information
- Product Name
- Substance P
- Catalog No.
- P-32050
- CAS No.
- 33507-63-0
- Sequence
- H-RPKPQQFFGLM-NH2
- Molecular Formula
- C63H97N17O14S
- Molecular Weight
- 1347.65
Peptide Depictor
11 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-RPKPQQFFGLM-NH2
Length
11.00
Molecular Weight
1346.73 Da
Monoisotopic Mass
1346.73 Da
Estimated Net Charge
2.000
pI
14.00
Hydrophobicity GRAVY
-0.7000
Physicochemical Properties
Basic Residue Ratio
18%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
18%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.02428————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.01638————0.3892 | Fouling |
| Solubility | score threshold | 0.9859————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8161————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.5085————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -9.700 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.852 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8152 | Model output only, not in-vivo half-life |