Active pentapeptide fragment of thymopoietin II (positions 32–36). Exhibits immunomodulatory activity and promotes T-cell differentiation and maturation. Used in research related to immunodeficiency, autoimmune diseases, and oncology adjuvant therapy. An alternative to thymosin α1. Research grade material for studies of immunomodulation, T-cell development, and the mechanism of action of thymic peptides.
Basic Information
- Product Name
- Thymopentin (TP-5)
- Catalog No.
- P-32049
- CAS No.
- 69558-55-0
- Sequence
- H-RKDVY-OH
- Molecular Formula
- C30H49N9O9
- Molecular Weight
- 679.77
Peptide Depictor
5 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-RKDVY-OH
Length
5.000
Molecular Weight
679.37 Da
Monoisotopic Mass
679.37 Da
Estimated Net Charge
1.000
pI
9.750
Hydrophobicity GRAVY
-1.800
Physicochemical Properties
Basic Residue Ratio
40%
Acidic Residue Ratio
20%
Aromatic Residue Ratio
20%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
HCl
- 疏水残基比例偏高，建议先小量溶解测试
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.7170————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.08551————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8423————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.6907————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -8.924 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.846 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7236 | Model output only, not in-vivo half-life |