Third-generation GnRH antagonist that competitively blocks the GnRH receptor. Used in IVF to prevent premature ovulation. Rapid onset of action with no flare effect. Research-grade material for studies of GnRH receptors, assisted reproduction, and antagonist pharmacology.
Basic Information
- Product Name
- Cetrorelix
- Catalog No.
- P-32048
- CAS No.
- —
- Sequence
- Ac-[d2Nal][d4Cpa][d3Pal]SYD[dCit]LRP[dA]-NH2
- Molecular Formula
- C42H67N13O14
- Molecular Weight
- 2114.30
Peptide Depictor
11 aa
Mouse wheel or pinch to zoom, drag to pan, click to show residue structure
Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
Ac-[d2Nal][d4Cpa][d3Pal]SYD[dCit]LRP[dA]-NH2
Length
11.00
Molecular Weight
1544.70 Da
Monoisotopic Mass
1544.70 Da
Estimated Net Charge
0.000
pI
6.860
Hydrophobicity GRAVY
-0.7180
Physicochemical Properties
Basic Residue Ratio
9%
Acidic Residue Ratio
9%
Aromatic Residue Ratio
9%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.3804————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02652————0.3892 | Fouling |
| Solubility | score threshold | 0.9791————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8227————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.04993————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -8.166 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.850 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.9015 | Model output only, not in-vivo half-life |