A third-generation GnRH antagonist that directly and competitively blocks the GnRH receptor, with no initial agonist phase (no flare effect). Used in prostate cancer treatment to rapidly reduce testosterone levels. Research grade, for studies of GnRH receptor antagonists, prostate cancer therapy, and endocrine drugs.
Basic Information
- Product Name
- Degarelix
- Catalog No.
- P-32047
- CAS No.
- —
- Sequence
- Ac-[d2Nal][d4Cpa][d3Pal]S[Aph](Hor)[dAph](Cbm)LK(iPr)P[dA]-NH2
- Molecular Formula
- C32H53N9O11
- Molecular Weight
- 2376.61
Peptide Depictor
10 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
Ac-[d2Nal][d4Cpa][d3Pal]S[Aph](Hor)[dAph](Cbm)LK(iPr)P[dA]-NH2
Length
10.00
Molecular Weight
1630.75 Da
Monoisotopic Mass
1630.75 Da
Estimated Net Charge
1.000
pI
14.00
Hydrophobicity GRAVY
-0.2500
Physicochemical Properties
Basic Residue Ratio
10%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
0%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.2346————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.03896————0.3892 | Fouling |
| Solubility | score threshold | 0.9756————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6063————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.02187————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -7.013 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.852 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8794 | Model output only, not in-vivo half-life |