A neuropeptide produced by alternative splicing of the calcitonin gene. A potent vasodilator involved in pain transmission, inflammation, and migraine. It is an important target in migraine therapy (CGRP monoclonal antibodies). Research-grade material for studies of migraine mechanisms, neurovascular regulation, pain, and CGRP receptor research.
Basic Information
- Product Name
- Calcitonin Gene-Related Peptide (CGRP)
- Catalog No.
- P-32039
- CAS No.
- 83652-28-2
- Sequence
- H-ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-OH {cyclo=disulfide:2-7}
- Molecular Formula
- C163H268N50O50S2
- Molecular Weight
- 3790.35
Peptide Depictor
37 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-OH {cyclo=disulfide:2-7}
Length
37.00
Molecular Weight
3787.93 Da
Monoisotopic Mass
3787.93 Da
Estimated Net Charge
3.100
pI
9.920
Hydrophobicity GRAVY
0.2110
Physicochemical Properties
Basic Residue Ratio
11%
Acidic Residue Ratio
3%
Aromatic Residue Ratio
5%
Cys Count
2.000
Oxidation-Risk Residues
2.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.8479————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.01710————0.3892 | Fouling |
| Solubility | score threshold | 0.4903————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.1309————0.5028 | Non-Penetrating |
| Toxicity Risk | score threshold | 0.1028————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -12.30 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.854 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.9736 | Model output only, not in-vivo half-life |