The primary effector peptide of the kinin system. A potent vasodilator that increases vascular permeability and induces pain and inflammation. Involved in inflammatory responses and blood pressure regulation. Also serves as an alternative substrate for ACE. Research-grade material for studies of inflammation, pain, vascular regulation, and the kallikrein-kinin system.
Basic Information
- Product Name
- Bradykinin
- Catalog No.
- P-32038
- CAS No.
- 58-82-2
- Sequence
- H-RPPGFSPFR-OH
- Molecular Formula
- C50H73N15O11
- Molecular Weight
- 1060.23
Peptide Depictor
9 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-RPPGFSPFR-OH
Length
9.000
Molecular Weight
1059.56 Da
Monoisotopic Mass
1059.56 Da
Estimated Net Charge
2.000
pI
12.48
Hydrophobicity GRAVY
-1.044
Physicochemical Properties
Basic Residue Ratio
22%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
22%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.0007279————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.07758————0.3892 | Fouling |
| Solubility | score threshold | 0.9838————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8556————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.9412————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -7.530 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.845 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7864 | Model output only, not in-vivo half-life |