A decapeptide generated by renin cleavage of angiotensinogen. It has low intrinsic activity and is converted to active Ang II by ACE-mediated removal of the two C-terminal amino acids. It is a substrate of ACE. Research-grade material for studies of the renin–angiotensin system, ACE enzyme activity, and mechanisms of hypertension.
Basic Information
- Product Name
- Angiotensin I (Human)
- Catalog No.
- P-32037
- CAS No.
- 484-42-4
- Sequence
- H-DRVYIHPFHL-OH
- Molecular Formula
- C62H89N17O14
- Molecular Weight
- 1296.50
Peptide Depictor
10 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-DRVYIHPFHL-OH
Length
10.00
Molecular Weight
1295.68 Da
Monoisotopic Mass
1295.68 Da
Estimated Net Charge
0.2000
pI
7.920
Hydrophobicity GRAVY
-0.2000
Physicochemical Properties
Basic Residue Ratio
10%
Acidic Residue Ratio
10%
Aromatic Residue Ratio
20%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.03090————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.2064————0.3892 | Fouling |
| Solubility | score threshold | 0.9645————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6568————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.4645————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -9.994 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.858 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 1.131 | Model output only, not in-vivo half-life |