The principal effector peptide of the renin-angiotensin system. A potent vasoconstrictor that stimulates aldosterone secretion, promotes sodium and water retention, and increases blood pressure. An important target in hypertension therapy. Research-grade material for studies of hypertension, the renin-angiotensin system, vascular regulation, and drug targets.
Basic Information
- Product Name
- Angiotensin II (Human)
- Catalog No.
- P-32036
- CAS No.
- 4474-91-3
- Sequence
- H-DRVYIHPF-OH
- Molecular Formula
- C50H71N13O12
- Molecular Weight
- 1046.19
Peptide Depictor
8 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-DRVYIHPF-OH
Length
8.000
Molecular Weight
1045.53 Da
Monoisotopic Mass
1045.53 Da
Estimated Net Charge
0.1000
pI
7.770
Hydrophobicity GRAVY
-0.3250
Physicochemical Properties
Basic Residue Ratio
13%
Acidic Residue Ratio
13%
Aromatic Residue Ratio
25%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.009673————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.1419————0.3892 | Fouling |
| Solubility | score threshold | 0.9834————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7264————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.3554————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -9.817 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.856 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8357 | Model output only, not in-vivo half-life |