A potent vasoconstrictor peptide secreted by vascular endothelial cells. Acts through ETA and ETB receptors to regulate vascular tone and cell proliferation. Involved in diseases such as hypertension, pulmonary arterial hypertension, and heart failure. Research-grade material for studies of vascular regulation, endothelial function, cardiovascular disease, and receptor pharmacology.
Basic Information
- Product Name
- Endothelin-1 (ET-1)
- Catalog No.
- P-32035
- CAS No.
- 117399-94-7
- Sequence
- H-CSCSSLMDKECVYFCHLDIIW-OH {cyclo=disulfide:1-15} {cyclo=disulfide:3-11}
- Molecular Formula
- C109H163N25O32S5
- Molecular Weight
- 2491.94
Peptide Depictor
21 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-CSCSSLMDKECVYFCHLDIIW-OH {cyclo=disulfide:1-15} {cyclo=disulfide:3-11}
Length
21.00
Molecular Weight
2490.02 Da
Monoisotopic Mass
2490.02 Da
Estimated Net Charge
-1.900
pI
4.180
Hydrophobicity GRAVY
0.6330
Physicochemical Properties
Basic Residue Ratio
5%
Acidic Residue Ratio
14%
Aromatic Residue Ratio
14%
Cys Count
4.000
Oxidation-Risk Residues
6.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.1902————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.05015————0.3892 | Fouling |
| Solubility | score threshold | 0.9834————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.4502————0.5028 | Non-Penetrating |
| Toxicity Risk | score threshold | 0.2910————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -9.115 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.848 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8422 | Model output only, not in-vivo half-life |