A renal form of ANP synthesized in the distal tubules of the kidney. It contains 4 additional amino acids at the N-terminus compared with ANP. Promotes natriuresis and diuresis, with greater potency than ANP. Used in research on acute heart failure treatment. Research grade for studies of renal natriuretic peptides, sodium and water metabolism, and heart failure.
Basic Information
- Product Name
- Ularitide (Urodilatin)
- Catalog No.
- P-32034
- CAS No.
- 118812-69-4
- Sequence
- H-TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY-OH {cyclo=disulfide:11-27}
- Molecular Formula
- C145H236N52O44S3
- Molecular Weight
- 3505.98
Peptide Depictor
32 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY-OH {cyclo=disulfide:11-27}
Length
32.00
Molecular Weight
3503.68 Da
Monoisotopic Mass
3503.68 Da
Estimated Net Charge
5.000
pI
11.79
Hydrophobicity GRAVY
-0.5910
Physicochemical Properties
Basic Residue Ratio
19%
Acidic Residue Ratio
3%
Aromatic Residue Ratio
9%
Cys Count
2.000
Oxidation-Risk Residues
3.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.3683————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02364————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8857————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.1395————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -12.98 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.853 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7523 | Model output only, not in-vivo half-life |