A member of the natriuretic peptide family, primarily expressed in vascular endothelium and the central nervous system. Acts through the NPR-B receptor and mainly regulates endochondral ossification and vascular tone. It has weak diuretic activity. Research-grade material for studies of skeletal development, vascular regulation, and natriuretic peptide receptor subtypes.
Basic Information
- Product Name
- C-type Natriuretic Peptide (CNP)
- Catalog No.
- P-32033
- CAS No.
- 127869-51-6
- Sequence
- H-GLSKGCFGLKLDRIGSMSGLGC-OH {cyclo=disulfide:6-22}
- Molecular Formula
- C93H159N27O28S3
- Molecular Weight
- 2197.64
Peptide Depictor
22 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-GLSKGCFGLKLDRIGSMSGLGC-OH {cyclo=disulfide:6-22}
Length
22.00
Molecular Weight
2196.09 Da
Monoisotopic Mass
2196.09 Da
Estimated Net Charge
2.000
pI
9.040
Hydrophobicity GRAVY
0.4000
Physicochemical Properties
Basic Residue Ratio
14%
Acidic Residue Ratio
5%
Aromatic Residue Ratio
5%
Cys Count
2.000
Oxidation-Risk Residues
3.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.4077————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.01698————0.3892 | Fouling |
| Solubility | score threshold | 0.9860————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8188————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.2408————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -11.80 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.848 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7923 | Model output only, not in-vivo half-life |