Recombinant human BNP, used for the treatment of acute decompensated heart failure. Administered by intravenous infusion; promotes vasodilation, reduces pulmonary capillary wedge pressure, and increases urinary sodium excretion. Research-grade material for studies of heart failure therapy, natriuretic peptide pharmacology, and cardiovascular drug research.
Basic Information
- Product Name
- Nesiritide
- Catalog No.
- P-32032
- CAS No.
- 124584-08-3
- Sequence
- H-SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH-OH {cyclo=disulfide:10-26}
- Molecular Formula
- C143H246N50O42S4
- Molecular Weight
- 3464.09
Peptide Depictor
32 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH-OH {cyclo=disulfide:10-26}
Length
32.00
Molecular Weight
3461.74 Da
Monoisotopic Mass
3461.74 Da
Estimated Net Charge
6.100
pI
11.45
Hydrophobicity GRAVY
-0.5060
Physicochemical Properties
Basic Residue Ratio
22%
Acidic Residue Ratio
3%
Aromatic Residue Ratio
3%
Cys Count
2.000
Oxidation-Risk Residues
4.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.2443————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.03107————0.3892 | Fouling |
| Solubility | score threshold | 0.9832————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8022————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.2487————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -12.89 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.850 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7923 | Model output only, not in-vivo half-life |