A cyclic lipopeptide antibiotic produced by Streptomyces fermentation. Disrupts the cell membrane of Gram-positive bacteria in a calcium-dependent manner. Used for infections caused by drug-resistant Gram-positive bacteria such as MRSA and VRE. Administered once daily. Research-grade material for studies of antibacterial mechanisms, membrane-targeting antibiotics, and treatment of drug-resistant bacterial infections.
Basic Information
- Product Name
- Daptomycin
- Catalog No.
- P-32028
- CAS No.
- —
- Sequence
- C10-W[dN]DTG[Orn]D[dA]DG[dS][3MeE][Kyn] {cyclo=lactone:4-13}
- Molecular Formula
- C57H75N15O25
- Molecular Weight
- 4656.71
Peptide Depictor
13 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
C10-W[dN]DTG[Orn]D[dA]DG[dS][3MeE][Kyn] {cyclo=lactone:4-13}
Length
13.00
Molecular Weight
1619.71 Da
Monoisotopic Mass
1619.71 Da
Estimated Net Charge
-3.000
pI
Not calculated
Hydrophobicity GRAVY
-0.9920
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
23%
Aromatic Residue Ratio
8%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
1.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.06146————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.1306————0.3892 | Fouling |
| Solubility | score threshold | 0.9859————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.1391————0.5028 | Non-Penetrating |
| Toxicity Risk | score threshold | 0.8294————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -9.790 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.842 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8552 | Model output only, not in-vivo half-life |