A hormone secreted by atrial cardiomyocytes that regulates sodium and water excretion and blood pressure. It promotes natriuresis, diuresis, and vasodilation, and inhibits the renin-angiotensin system. Levels are elevated in heart failure. Research-grade material for studies of cardiovascular regulation, sodium and water metabolism, heart failure, and natriuretic peptide receptors.
Basic Information
- Product Name
- Atrial Natriuretic Peptide (ANP)
- Catalog No.
- P-32030
- CAS No.
- 1366000-58-9
- Sequence
- H-SLRRSSCFGGRMDRIGAQSGLGCNSFRY-OH {cyclo=disulfide:7-23}
- Molecular Formula
- C127H205N45O39S3
- Molecular Weight
- 3080.49
Peptide Depictor
28 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-SLRRSSCFGGRMDRIGAQSGLGCNSFRY-OH {cyclo=disulfide:7-23}
Length
28.00
Molecular Weight
3078.44 Da
Monoisotopic Mass
3078.44 Da
Estimated Net Charge
4.000
pI
10.99
Hydrophobicity GRAVY
-0.4960
Physicochemical Properties
Basic Residue Ratio
18%
Acidic Residue Ratio
4%
Aromatic Residue Ratio
11%
Cys Count
2.000
Oxidation-Risk Residues
3.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.2932————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02850————0.3892 | Fouling |
| Solubility | score threshold | 0.9860————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8658————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.1062————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -13.24 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.854 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7523 | Model output only, not in-vivo half-life |