The active octapeptide fragment of cholecystokinin; tyrosine sulfation is essential for activity. It stimulates gallbladder contraction and pancreatic enzyme secretion, and inhibits gastric emptying. CCK-8 is a high-affinity ligand for CCK receptors. Research grade, for studies of CCK receptors, digestive physiology, appetite regulation, and pain.
Basic Information
- Product Name
- Cholecystokinin-8 (CCK-8)
- Catalog No.
- P-32022
- CAS No.
- —
- Sequence
- H-DY(SO3)MGWMDF-NH2
- Molecular Formula
- C49H61N9O17S3
- Molecular Weight
- 1063.22
Peptide Depictor
8 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-DY(SO3)MGWMDF-NH2
Length
8.000
Molecular Weight
1142.35 Da
Monoisotopic Mass
1142.35 Da
Estimated Net Charge
-2.000
pI
3.650
Hydrophobicity GRAVY
-0.3750
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
25%
Aromatic Residue Ratio
38%
Cys Count
0.000
Oxidation-Risk Residues
3.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
acetate
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.07006————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.1078————0.3892 | Fouling |
| Solubility | score threshold | 0.9858————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.3700————0.5028 | Non-Penetrating |
| Toxicity Risk | score threshold | 0.09702————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -10.41 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.861 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7985 | Model output only, not in-vivo half-life |