A second-generation somatostatin analog with high affinity for SSTR1, SSTR2, SSTR3, and SSTR5, particularly SSTR5. Used in the treatment of Cushing's disease and acromegaly. Its broad-spectrum receptor binding may make it effective in certain resistant cases. Research grade, for studies of somatostatin receptor profiles, Cushing's syndrome, and tumor therapy.
Basic Information
- Product Name
- Pasireotide
- Catalog No.
- P-32020
- CAS No.
- —
- Sequence
- [Hyp](Aec)[Phg][dW]KY(Bn)F {cyclo=head_to_tail}
- Molecular Formula
- C53H60N8O8
- Molecular Weight
- 770.89
Peptide Depictor
6 aa
Mouse wheel or pinch to zoom, drag to pan, click to show residue structure
Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
[Hyp](Aec)[Phg][dW]KY(Bn)F {cyclo=head_to_tail}
Length
6.000
Molecular Weight
1046.50 Da
Monoisotopic Mass
1046.50 Da
Estimated Net Charge
1.000
pI
9.750
Hydrophobicity GRAVY
-0.4000
Physicochemical Properties
Basic Residue Ratio
17%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
33%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.004068————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.03885————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7875————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.9586————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -7.232 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.851 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8688 | Model output only, not in-vivo half-life |