GHRH analog with an N-terminal trans-hexenoic acid modification to enhance stability. Used for the treatment of HIV-associated lipodystrophy. Stimulates growth hormone release and improves body fat distribution. Research grade for studies of GHRH analogs, metabolic syndrome, and fat distribution.
Basic Information
- Product Name
- Tesamorelin
- Catalog No.
- P-32014
- CAS No.
- —
- Sequence
- t3C6-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2
- Molecular Formula
- C215H357N71O67S
- Molecular Weight
- 6355.09
Peptide Depictor
44 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
t3C6-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2
Length
44.00
Molecular Weight
5132.72 Da
Monoisotopic Mass
5132.72 Da
Estimated Net Charge
4.000
pI
11.32
Hydrophobicity GRAVY
-0.7980
Physicochemical Properties
Basic Residue Ratio
18%
Acidic Residue Ratio
9%
Aromatic Residue Ratio
7%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.5497————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.006523————0.3892 | Fouling |
| Solubility | score threshold | 0.9831————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.4947————0.5028 | Non-Penetrating |
| Toxicity Risk | score threshold | 0.006210————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -11.69 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.851 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 1.456 | Model output only, not in-vivo half-life |