The N-terminal 29-amino acid fragment of growth hormone-releasing hormone (GHRH) and the minimal active fragment of GHRH. Stimulates pituitary growth hormone release via the GHRH receptor. Used in the diagnosis of growth hormone deficiency. Research-grade material for studies of the GHRH receptor, regulation of the growth hormone axis, and endocrinology.
Basic Information
- Product Name
- Sermorelin
- Catalog No.
- P-32013
- CAS No.
- 86168-78-7
- Sequence
- H-YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2
- Molecular Formula
- C149H245N43O43S
- Molecular Weight
- 3357.93
Peptide Depictor
29 aa
Mouse wheel or pinch to zoom, drag to pan, click to show residue structure
Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2
Length
29.00
Molecular Weight
3355.82 Da
Monoisotopic Mass
3355.82 Da
Estimated Net Charge
3.000
pI
10.81
Hydrophobicity GRAVY
-0.2210
Physicochemical Properties
Basic Residue Ratio
17%
Acidic Residue Ratio
7%
Aromatic Residue Ratio
10%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.6757————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.01691————0.3892 | Fouling |
| Solubility | score threshold | 0.9859————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.1980————0.5028 | Non-Penetrating |
| Toxicity Risk | score threshold | 0.2650————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -11.04 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.850 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.5748 | Model output only, not in-vivo half-life |