GLP-1 receptor agonist engineered based on exendin-4. Six lysine residues at the C-terminus extend the half-life. Used for once-daily injection in the treatment of type 2 diabetes. Research-grade material for studies of GLP-1 receptor pharmacology and peptide drug half-life extension strategies.
Basic Information
- Product Name
- Lixisenatide
- Catalog No.
- P-32005
- CAS No.
- 320367-13-3
- Sequence
- H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2
- Molecular Formula
- C215H346N60O66S
- Molecular Weight
- 4858.56
Peptide Depictor
44 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK-NH2
Length
44.00
Molecular Weight
4855.54 Da
Monoisotopic Mass
4855.54 Da
Estimated Net Charge
3.100
pI
10.35
Hydrophobicity GRAVY
-1.109
Physicochemical Properties
Basic Residue Ratio
21%
Acidic Residue Ratio
14%
Aromatic Residue Ratio
7%
Cys Count
0.000
Oxidation-Risk Residues
2.000
Asp-Gly / Asn-Gly
1.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.1929————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02267————0.3892 | Fouling |
| Solubility | score threshold | 0.9799————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.5473————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.03830————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -14.46 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.859 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.9920 | Model output only, not in-vivo half-life |