A dual GIP/GLP-1 receptor agonist used for the treatment of type 2 diabetes and obesity. It activates both GIP and GLP-1 receptors, with greater weight-reduction effects than single GLP-1 agonists. Administered once weekly. Research-grade material for studies of metabolic syndrome, obesity mechanisms, and dual-receptor synergy.
Basic Information
- Product Name
- Tirzepatide
- Catalog No.
- P-32004
- CAS No.
- 2023788-19-2
- Sequence
- H-Y[Aib]EGTFTSDYSI[Aib]LDKIAQK([AEEA][AEEA][γGlu][C20DA])AFVQWLIAGGPSSGAPPPS-NH2
- Molecular Formula
- C213H325N45O65
- Molecular Weight
- 4725.41
Peptide Depictor
39 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-Y[Aib]EGTFTSDYSI[Aib]LDKIAQK([AEEA][AEEA][gGlu][C20DA])AFVQWLIAGGPSSGAPPPS-NH2
Length
39.00
Molecular Weight
4722.47 Da
Monoisotopic Mass
4722.47 Da
Estimated Net Charge
-1.000
pI
6.890
Hydrophobicity GRAVY
-0.1050
Physicochemical Properties
Basic Residue Ratio
5%
Acidic Residue Ratio
8%
Aromatic Residue Ratio
13%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.03706————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.01606————0.3892 | Fouling |
| Solubility | score threshold | 0.9824————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6401————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.1017————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -13.25 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.862 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7976 | Model output only, not in-vivo half-life |