A GLP-1 receptor agonist, exendin-4 isolated from Gila monster saliva. Used for the treatment of type 2 diabetes with twice-daily injection. Half-life is approximately 2.4 hours. Research grade for studies of GLP-1 receptor pharmacology, diabetes treatment mechanisms, and pancreatic islet function.
Basic Information
- Product Name
- Exenatide
- Catalog No.
- P-32003
- CAS No.
- 141732-76-5
- Sequence
- H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
- Molecular Formula
- C184H281N49O61S
- Molecular Weight
- 4186.63
Peptide Depictor
39 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Length
39.00
Molecular Weight
4184.03 Da
Monoisotopic Mass
4184.03 Da
Estimated Net Charge
-2.900
pI
4.850
Hydrophobicity GRAVY
-0.6920
Physicochemical Properties
Basic Residue Ratio
8%
Acidic Residue Ratio
15%
Aromatic Residue Ratio
8%
Cys Count
0.000
Oxidation-Risk Residues
2.000
Asp-Gly / Asn-Gly
1.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.1290————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02629————0.3892 | Fouling |
| Solubility | score threshold | 0.9792————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.5291————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.03882————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -14.24 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.858 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 1.084 | Model output only, not in-vivo half-life |