GLP-1 receptor agonist used for the treatment of type 2 diabetes and obesity. Its half-life is extended through binding to albumin via a fatty acid side chain (approximately 13 hours). Administered once daily by subcutaneous injection. Research-grade material for studies of GLP-1 receptor signaling pathways, metabolic regulation, and mechanisms of obesity.
Basic Information
- Product Name
- Liraglutide
- Catalog No.
- P-32002
- CAS No.
- 204656-20-2
- Sequence
- H-HAEGTFTSDVSSYLEGQAAKEFIAWLVRGRG-OH
- Molecular Formula
- C151H228N42O47
- Molecular Weight
- 3383.72
Peptide Depictor
31 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-HAEGTFTSDVSSYLEGQAAKEFIAWLVRGRG-OH
Length
31.00
Molecular Weight
3381.67 Da
Monoisotopic Mass
3381.67 Da
Estimated Net Charge
-0.9000
pI
5.420
Hydrophobicity GRAVY
-0.2550
Physicochemical Properties
Basic Residue Ratio
10%
Acidic Residue Ratio
13%
Aromatic Residue Ratio
13%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.7066————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.02208————0.3892 | Fouling |
| Solubility | score threshold | 0.9855————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6770————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.04575————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -15.18 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.861 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8552 | Model output only, not in-vivo half-life |