A GLP-1 receptor agonist used for the treatment of type 2 diabetes and weight management in obesity. It promotes insulin secretion, suppresses glucagon secretion, delays gastric emptying, and reduces appetite by activating the GLP-1 receptor. It has a long half-life (approximately 1 week) and is administered once weekly. Research-grade material for studies of drug metabolism, pharmacological mechanisms, and receptor binding.
Basic Information
- Product Name
- Semaglutide
- Catalog No.
- P-32001
- CAS No.
- 910463-68-2
- Sequence
- H-H[Aib]EGTFTSDVSSYLEGQAAK([AEEA][AEEA][γGlu][C18DA])EFIAWLVRGRG-OH
- Molecular Formula
- C179H276N44O56
- Molecular Weight
- 4025.53
Peptide Depictor
31 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-H[Aib]EGTFTSDVSSYLEGQAAK([AEEA][AEEA][gGlu][C18DA])EFIAWLVRGRG-OH
Length
31.00
Molecular Weight
4023.06 Da
Monoisotopic Mass
4023.06 Da
Estimated Net Charge
-0.9000
pI
5.420
Hydrophobicity GRAVY
-0.3130
Physicochemical Properties
Basic Residue Ratio
10%
Acidic Residue Ratio
13%
Aromatic Residue Ratio
13%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.5910————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.01100————0.3892 | Fouling |
| Solubility | score threshold | 0.9856————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6901————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.05519————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -14.88 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.861 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8691 | Model output only, not in-vivo half-life |