Search titles, summaries, tags and full article text.
Mass Spectrometry & Applications2026/6/24
Design Principles for Delta MS Between Isotopic Internal Standards and Target Molecules
The rational design of Delta MS requires integrating molecular weight, natural isotope distribution, and elemental composition. For large molecules containing two chlorine atoms, such as vancomycin, Vancomycin-D10 can provide a sufficient mass difference for reliable internal standard correction in LC-MS/MS quantification.
Delta MSDelta MassStable Isotope Internal StandardsLC-MS/MS
Peptide Synthesis & Purification2026/6/24
Why Is 95% Purity Usually Chosen for Research-Grade Peptides?
95% purity is typically the standard specification for research-grade peptides. This article analyzes its suitability for cell-based experiments, protein interactions, antibody development, and functional validation, and explains when it is necessary to select a purity of 98% or 99% or higher.
Peptide Synthesis & Purification2026/6/24
How Should Peptide Purity Be Selected? Application Areas and Cost-Effectiveness Analysis of Peptides with Different Purity Levels
Higher peptide purity is not necessarily better. This article systematically explains the appropriate use cases for crude peptides and peptides with purities of 70%–85%, 95%, 98%, and above 99%, helping users in scientific research and drug development select a more appropriate purity grade based on their experimental objectives.
Cyclic Peptides
Peptide Synthesis & Purification2026/6/24
A Systematic Analysis of Peptide Synthesis Difficulty: Effects of Sequence, Length, Cyclization, and Chemical Modification
The difficulty of peptide synthesis is not determined by chain length alone, but by the combined effects of sequence composition, coupling efficiency, cyclization strategy, and chemical modifications. This article systematically analyzes the key factors that affect the success rate, purity, and purification difficulty of SPPS.
cyclic peptidepeptide modificationSPPSpeptide design
Peptide Drugs & Applications2026/6/24
From Semaglutide to Oral Macrocycles: How Noncanonical Amino Acids Transform Peptide Medicines
Using seven approved peptide drugs as examples, this article explains how Aib, D-amino acids, N-methylation, fatty diacids, and other specialized residues work together to improve stability, conformation, target recognition, and pharmacokinetics.
noncanonical amino acidspeptide drugsAibD-amino acids
Noncanonical Amino Acids & Peptide Design2026/6/24
AI-Assisted Peptide Design: From Sequence to Drug Candidate
Artificial intelligence is transforming peptide R&D workflows. From sequence analysis and structure prediction to the generation of candidate molecules, AI-assisted design is helping researchers more rapidly discover novel peptide candidates with stability, activity, and development potential.
AI-Assisted Peptide DesignPeptide DesignCyclic PeptidesNon-natural Amino Acids
Peptide Drugs & Applications2026/6/24
Cyclic Peptide Design Guide: Why Cyclic Peptides Are Becoming Increasingly Important
Cyclic peptides significantly improve peptide stability, binding capacity, and pharmacokinetic properties through conformational constraints, and provide new directions for the development of oral peptide drugs and difficult-to-drug targets.
Cyclic PeptidesPeptide DesignPeptide DrugsNon-natural Amino Acids
Peptide Synthesis & Purification2026/6/24
Guide to Custom Peptide Synthesis: How to Obtain High-Quality Peptide Products?
Custom peptides involve more than simply providing an amino acid sequence. This article introduces key factors such as peptide sequence, purity, modifications, cyclization strategies, unnatural amino acids, and AI-assisted design, helping researchers obtain higher-quality peptide products.
Cyclic PeptidesNon-natural Amino AcidsAI-Assisted Peptide Design
Stable Isotopes & Labeling Chemistry2026/6/24
Deuteration Is Not Just for Mass Spectrometry Internal Standards: Isotope Effects from Deuterated Drugs to OLED Materials
Deuterated chemistry is used not only for mass spectrometry internal standards, but can also alter the metabolism, degradation, and aging processes of molecules through the kinetic isotope effect, demonstrating application value in deuterated drugs, OLED materials, and highly stable functional raw materials.
Mass Spectrometry & Applications2026/6/24
Vancomycin Testing: Comparison of LC-MS/MS and Immunoassays
The therapeutic concentration of vancomycin is close to its toxic concentration, making precise therapeutic drug monitoring essential for individualized dosing. This article compares the characteristics of immunoassays and LC-MS/MS methods in vancomycin testing and explains the central role of stable isotope-labeled internal standards in high-quality quantitative mass spectrometry.
Therapeutic Drug MonitoringLC-MS/MSClinical Mass SpectrometryStable Isotope Internal Standards
Mass Spectrometry & Applications2026/6/24
Why Is Mass Spectrometry the Gold Standard for Small-Molecule Analysis?
LC-MS/MS has become the gold standard for small-molecule analysis. Its core advantages include: achieving highly precise quantification based on stable isotope-labeled internal standards, simultaneously detecting dozens of analytes in a single analysis, and accurately distinguishing compounds with highly similar structures.
LC-MS/MSStable Isotope Internal StandardsClinical Mass SpectrometryQuantitative Analysis
Mass Spectrometry & Applications2026/6/24
Selection of Stable Isotope Internal Standards: Why Are 13C/15N-Labeled Standards Usually Superior to Deuterated Internal Standards?
13C- and 15N-labeled internal standards generally offer better chromatographic consistency and long-term stability, whereas deuterated internal standards have a clear cost advantage. This article introduces the advantages, disadvantages, and application scenarios of different stable isotope labeling strategies.
Internal StandardsLC-MS/MSIDMS