Basic Information
- Product Name
- LEAP-2
- Catalog No.
- P-31003
- CAS No.
- —
- Sequence
- H-MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE-OH {cyclo=disulfide:17-28} {cyclo=disulfide:23-33}
- Molecular Formula
- C191H320N64O57S5
- Molecular Weight
- 4581.34
Peptide Depictor
40 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE-OH {cyclo=disulfide:17-28} {cyclo=disulfide:23-33}
Length
40.00
Molecular Weight
4578.24 Da
Monoisotopic Mass
4578.24 Da
Estimated Net Charge
4.000
pI
9.240
Hydrophobicity GRAVY
-0.4030
Physicochemical Properties
Basic Residue Ratio
20%
Acidic Residue Ratio
10%
Aromatic Residue Ratio
5%
Cys Count
4.000
Oxidation-Risk Residues
6.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.2953————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.007443————0.3892 | Fouling |
| Solubility | score threshold | 0.8297————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6913————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.007985————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -15.67 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.852 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8392 | Model output only, not in-vivo half-life |