An opioid peptide isolated from frog skin, containing a D-amino acid (naturally occurring D-amino acid peptides are rare). A potent μ-opioid receptor agonist with analgesic activity stronger than morphine. Resistant to enzymatic degradation and highly stable. Research-grade material for studies of opioid receptors, naturally occurring D-amino acid peptides, and analgesic mechanisms.
Basic Information
- Product Name
- Dermorphin
- Catalog No.
- P-32058
- CAS No.
- 77614-16-5
- Sequence
- H-Y[dA]FGYPS-NH2
- Molecular Formula
- C40H49N7O11
- Molecular Weight
- 802.88
Peptide Depictor
7 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-Y[dA]FGYPS-NH2
Length
7.000
Molecular Weight
802.37 Da
Monoisotopic Mass
802.37 Da
Estimated Net Charge
0.000
pI
9.630
Hydrophobicity GRAVY
-0.3710
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
43%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.0002165————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.1955————0.3892 | Fouling |
| Solubility | score threshold | 0.9858————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.5895————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.9112————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -8.163 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.856 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.9913 | Model output only, not in-vivo half-life |