An endogenous opioid peptide generated by cleavage of the POMC precursor. A potent μ-opioid receptor agonist with analgesic activity stronger than morphine. Involved in analgesia, reward, stress, and mood regulation. Release increases after exercise (“runner’s high”). Research grade for studies of the opioid system, pain, exercise physiology, and mood regulation.
Basic Information
- Product Name
- β-Endorphin (Human)
- Catalog No.
- P-32056
- CAS No.
- 61214-51-5
- Sequence
- H-YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE-OH
- Molecular Formula
- C158H251N39O46S
- Molecular Weight
- 3465.03
Peptide Depictor
31 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE-OH
Length
31.00
Molecular Weight
3462.82 Da
Monoisotopic Mass
3462.82 Da
Estimated Net Charge
3.000
pI
10.07
Hydrophobicity GRAVY
-0.4580
Physicochemical Properties
Basic Residue Ratio
16%
Acidic Residue Ratio
7%
Aromatic Residue Ratio
13%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.4392————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02014————0.3892 | Fouling |
| Solubility | score threshold | 0.9843————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6028————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.5587————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -13.35 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.860 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8552 | Model output only, not in-vivo half-life |