Endogenous opioid peptide and highly selective κ-opioid receptor agonist. The N-terminal pentapeptide corresponds to the Leu-enkephalin sequence. Involved in analgesia, stress, mood regulation, and reward. κ-receptor activation is often associated with aversive effects. Research grade, for studies of opioid receptor subtypes, pain, stress, mood, and drug addiction.
Basic Information
- Product Name
- Dynorphin A
- Catalog No.
- P-32055
- CAS No.
- 72957-38-1
- Sequence
- H-YGGFLRRIRPKLK-OH
- Molecular Formula
- C75H126N24O15
- Molecular Weight
- 1603.98
Peptide Depictor
13 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-YGGFLRRIRPKLK-OH
Length
13.00
Molecular Weight
1602.98 Da
Monoisotopic Mass
1602.98 Da
Estimated Net Charge
5.000
pI
12.21
Hydrophobicity GRAVY
-0.7770
Physicochemical Properties
Basic Residue Ratio
39%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
15%
Cys Count
0.000
Oxidation-Risk Residues
0.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
HCl
- 疏水残基比例偏高，建议先小量溶解测试
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.01102————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02386————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8607————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.8249————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -9.386 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.849 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8516 | Model output only, not in-vivo half-life |