GnRH agonist analog with D-Leu6 and Pro9-NHEt modifications that enhance stability and receptor affinity. After initial stimulation, continuous administration leads to desensitization of pituitary GnRH receptors and inhibits gonadotropin secretion. Used in prostate cancer, breast cancer, endometriosis, and precocious puberty. Research-grade material for studies of GnRH receptors, endocrine therapy, and hormone-based cancer therapy.
Basic Information
- Product Name
- Leuprolide (Leuprorelin)
- Catalog No.
- P-32041
- CAS No.
- 53714-56-0
- Sequence
- [Pyr]HWSY[dL]LRP-NHEt
- Molecular Formula
- C52H74N14O11
- Molecular Weight
- 1225.39
Peptide Depictor
9 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
[Pyr]HWSY[dL]LRP-NHEt
Length
9.000
Molecular Weight
1224.64 Da
Monoisotopic Mass
1224.64 Da
Estimated Net Charge
1.100
pI
11.36
Hydrophobicity GRAVY
-0.9440
Physicochemical Properties
Basic Residue Ratio
11%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
22%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 未发现明显溶解性风险
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.1725————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.01441————0.3892 | Fouling |
| Solubility | score threshold | 0.9856————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7131————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.5187————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -8.176 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.855 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.7961 | Model output only, not in-vivo half-life |