Native somatostatin, a cyclic tetradecapeptide. Widely distributed in central and peripheral tissues, it inhibits the secretion of multiple hormones (GH, TSH, insulin, glucagon, gastrin, etc.). It has a very short half-life (2–3 minutes). Research grade, for studies of somatostatin physiological function, receptor subtypes, and endocrine regulation.
Basic Information
- Product Name
- Somatostatin-14 (SST-14)
- Catalog No.
- P-32018
- CAS No.
- 51110-01-1
- Sequence
- H-AGCKNFFWKTFTSC-OH {cyclo=disulfide:3-14}
- Molecular Formula
- C76H106N18O19S2
- Molecular Weight
- 1637.91
Peptide Depictor
14 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-AGCKNFFWKTFTSC-OH {cyclo=disulfide:3-14}
Length
14.00
Molecular Weight
1636.72 Da
Monoisotopic Mass
1636.72 Da
Estimated Net Charge
2.000
pI
9.040
Hydrophobicity GRAVY
0.02900
Physicochemical Properties
Basic Residue Ratio
14%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
29%
Cys Count
2.000
Oxidation-Risk Residues
3.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Moderate
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
TFA
- 疏水残基比例偏高，建议先小量溶解测试
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.1613————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.03657————0.3892 | Fouling |
| Solubility | score threshold | 0.9859————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.7528————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.1953————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -6.523 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.846 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8361 | Model output only, not in-vivo half-life |