Somatostatin analog with a cyclic octapeptide structure. Selectively binds SSTR2 and SSTR5 and inhibits the secretion of multiple hormones, including growth hormone, insulin, and glucagon. Half-life is approximately 90–120 minutes. Used for acromegaly, carcinoid syndrome, and esophageal variceal bleeding. Research-grade material for studies of somatostatin receptors, endocrine regulation, and cancer therapy.
Basic Information
- Product Name
- Octreotide
- Catalog No.
- P-32016
- CAS No.
- 83150-76-9
- Sequence
- H-[dF]CF[dW]KTCT-OL {cyclo=disulfide:2-7}
- Molecular Formula
- C49H66N10O11S2
- Molecular Weight
- 1019.26
Peptide Depictor
8 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-[dF]CF[dW]KTCT-OL {cyclo=disulfide:2-7}
Length
8.000
Molecular Weight
1018.44 Da
Monoisotopic Mass
1018.44 Da
Estimated Net Charge
1.000
pI
9.070
Hydrophobicity GRAVY
0.3120
Physicochemical Properties
Basic Residue Ratio
13%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
13%
Cys Count
2.000
Oxidation-Risk Residues
2.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Good
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Use with caution
DMSO Solubility Tendency
Moderate
Recommended Delivery Form
free
- 含多个Cys，溶解和氧化状态需同步控制
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.01601————0.5640 | Non-hemolytic |
| Non-Fouling | score threshold | 0.02990————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6953————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.9482————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -5.850 | PAMPA prediction: higher passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.844 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8361 | Model output only, not in-vivo half-life |