The naturally active amidated form of GLP-1 and the predominant active form in vivo. It exhibits activity comparable to or slightly higher than GLP-1(7-37). Research grade; used for studies of GLP-1 receptor binding, signal transduction, and mechanisms of insulin secretion.
Basic Information
- Product Name
- GLP-1 (7-36) amide
- Catalog No.
- P-32007
- CAS No.
- 107444-51-9
- Sequence
- H-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
- Molecular Formula
- C149H225N39O46
- Molecular Weight
- 3297.67
Peptide Depictor
30 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
H-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Length
30.00
Molecular Weight
3295.66 Da
Monoisotopic Mass
3295.66 Da
Estimated Net Charge
-0.9000
pI
7.740
Hydrophobicity GRAVY
-0.2300
Physicochemical Properties
Basic Residue Ratio
10%
Acidic Residue Ratio
13%
Aromatic Residue Ratio
13%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Use with caution
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.8102————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.01841————0.3892 | Fouling |
| Solubility | score threshold | 0.9860————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.6408————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.05204————0.4900 | Non-Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -14.89 | PAMPA prediction: lower passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.861 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8422 | Model output only, not in-vivo half-life |