Stable-Isotope Standards, Labeled Materials & Synthesis

A combined path through internal-standard selection and labeling chemistry, from ¹³C/¹⁵N and deuterium strategies to isotope effects, Delta MS and quantitative applications.

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Mass Spectrometry & Applications2026/6/24

Selection of Stable Isotope Internal Standards: Why Are 13C/15N-Labeled Standards Usually Superior to Deuterated Internal Standards?

13C- and 15N-labeled internal standards generally offer better chromatographic consistency and long-term stability, whereas deuterated internal standards have a clear cost advantage. This article introduces the advantages, disadvantages, and application scenarios of different stable isotope labeling strategies.

Internal StandardsLC-MS/MSIDMS

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Stable Isotopes & Labeling Chemistry2026/6/24

Deuteration Is Not Just for Mass Spectrometry Internal Standards: Isotope Effects from Deuterated Drugs to OLED Materials

Deuterated chemistry is used not only for mass spectrometry internal standards, but can also alter the metabolism, degradation, and aging processes of molecules through the kinetic isotope effect, demonstrating application value in deuterated drugs, OLED materials, and highly stable functional raw materials.

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Mass Spectrometry & Applications2026/6/24

Design Principles for Delta MS Between Isotopic Internal Standards and Target Molecules

The rational design of Delta MS requires integrating molecular weight, natural isotope distribution, and elemental composition. For large molecules containing two chlorine atoms, such as vancomycin, Vancomycin-D10 can provide a sufficient mass difference for reliable internal standard correction in LC-MS/MS quantification.

Delta MSDelta MassStable Isotope Internal StandardsLC-MS/MS

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Mass Spectrometry & Applications2026/6/24

Vancomycin Testing: Comparison of LC-MS/MS and Immunoassays

The therapeutic concentration of vancomycin is close to its toxic concentration, making precise therapeutic drug monitoring essential for individualized dosing. This article compares the characteristics of immunoassays and LC-MS/MS methods in vancomycin testing and explains the central role of stable isotope-labeled internal standards in high-quality quantitative mass spectrometry.

Therapeutic Drug MonitoringLC-MS/MSClinical Mass SpectrometryStable Isotope Internal Standards

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