Basic Information
- Product Name
- Cyclo(Leu-Trp)
- Catalog No.
- P-31046
- CAS No.
- —
- Sequence
- LW {cyclo=head_to_tail}
- Molecular Formula
- C17H23N3O3
- Molecular Weight
- 500.64
Peptide Depictor
2 aa
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Natural AA
Non-natural AA
Linker-like
Side-chain mod
Unknown
Acidic
Basic
Hydrophobic
Aromatic
Modified
Disulfide bond
Cyclization bond
AI-Assisted Peptide Property AnalysisShowHide
Sequence Overview
LW {cyclo=head_to_tail}
Length
2.000
Molecular Weight
299.16 Da
Monoisotopic Mass
299.16 Da
Estimated Net Charge
0.000
pI
6.010
Hydrophobicity GRAVY
1.450
Physicochemical Properties
Basic Residue Ratio
0%
Acidic Residue Ratio
0%
Aromatic Residue Ratio
50%
Cys Count
0.000
Oxidation-Risk Residues
1.000
Asp-Gly / Asn-Gly
0.000
Solubility Analysis
Water Solubility
Poor
Acidic Aqueous Compatibility
Suitable
Basic Aqueous Compatibility
Suitable
DMSO Solubility Tendency
likely_good
Recommended Delivery Form
TFA
- 疏水残基比例或连续疏水片段较高，水溶性可能较差
- 净电荷较低且疏水性偏高，可能需要DMSO或酸性/碱性条件辅助
Calculation Parameters
Calculated parameters are model predictions for research design, candidate comparison, and project evaluation only. They are not experimental measurements or final synthesis outcomes.
| Property | Parameter | Value | Result |
|---|---|---|---|
| Hemolysis Risk | score threshold | 0.8610————0.5640 | Hemolytic |
| Non-Fouling | score threshold | 0.02006————0.3892 | Fouling |
| Solubility | score threshold | 0.9861————0.3290 | Soluble |
| Cell-Penetrating Potential | score threshold | 0.8559————0.5028 | Cell-Penetrating |
| Toxicity Risk | score threshold | 0.5750————0.4900 | Toxic |
| PAMPA Passive Membrane Permeability | predicted value | -5.556 | PAMPA prediction: higher passive membrane permeability |
| Caco-2 Permeability | predicted value | -5.833 | Caco-2 prediction: higher cell-model permeability |
| Half-Life Model Output | model output | 0.8422 | Model output only, not in-vivo half-life |