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R-11058

Lamivudine (13C,15N2,d2)

Stable isotope standard for analytical research and method development.

Module Type
Stable Isotope Standards
Category
Drugs & TDM
CAS
134678-17-4
Unlabeled CAS
134678-17-4
PubChem CID
76973675
Molecular Formula
C7[13C]H9D2N[15N]2O3S
Molecular Weight
234.25
AI Isotope Property & Application AnalysisShow

Isotope Summary

Labels
D2, 15N2, 13C
Labeled atoms
5
Isotope positions
Confirmed in structure
Calculation reliability
High, based on explicit isotope structure

Mass & MS Parameters

Unlabeled exact mass
229.052112 Da
Labeled exact mass
234.06209 Da
Exact mass shift
5.009978 Da
Nominal mass shift
5
Ionm/zStatus
[M+H]+235.069367Theoretical
[M+Na]+257.051308Theoretical
[M+NH4]+252.095913Theoretical
[M-H]-233.054814Theoretical

Label Stability

Overall
Moderate risk
Calculation reliability
Medium, some information should be confirmed
  • Carbon-bound deuterium is evaluated by local chemical environment; isotope effects should still be checked experimentally.

Internal Standard Suitability

Rating
Medium
Chromatographic similarity
Possible isotope effect
Natural isotope overlap
Low
  • Exact mass separation is 5.009978 Da; MS channel separation should be verified in the final method.
  • The unlabeled parent mass was derived from the isotope structure because a curated parent structure was not matched.
  • Overall suitability: Medium.

Recommended Applications

LC-MS/MS Quantitative Internal Standard
Recommended

LC-MS/MS Quantitative Internal Standard is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

Isotope Dilution Mass Spectrometry
Recommended

Isotope Dilution Mass Spectrometry is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

GC-MS Internal Standard
Possible

GC-MS Internal Standard is classified as Possible based on isotope mapping, mass separation, and label-stability rules.

Metabolic Tracing
Not primary

Metabolic Tracing is classified as Not primary based on isotope mapping, mass separation, and label-stability rules.

Clinical Mass Spectrometry
Possible

Clinical Mass Spectrometry is classified as Possible based on isotope mapping, mass separation, and label-stability rules.

AI Interpretation

This analysis is based on isotope-aware structure data. The compound contains D2, 15N2, 13C, with an exact mass shift of 5.009978 Da. Label stability is assessed as Moderate risk, and internal-standard suitability is Medium. These results support analytical method development and require experimental validation.

AI-assisted analytical guidance is intended for method-development support. Actual isotope stability, chromatographic behavior, fragmentation and MRM transitions should be experimentally validated.