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R-10051

25-hydroxyvitamin D3 (6,19,19-D3)

Stable isotope standard for analytical research and method development.

Module Type
Stable Isotope Standards
Category
Metabolites
CAS
140710-94-7
Unlabeled CAS
1262843-45-7
PubChem CID
71314475
Molecular Formula
C27H41D3O2
Molecular Weight
403.7
AI Isotope Property & Application AnalysisShow

Isotope Summary

Labels
D3
Labeled atoms
3
Isotope positions
Partially confirmed in structure
Calculation reliability
Medium, some information should be confirmed

Mass & MS Parameters

Unlabeled exact mass
400.334131 Da
Labeled exact mass
403.352961 Da
Exact mass shift
3.01883 Da
Nominal mass shift
3
Ionm/zStatus
[M+H]+404.360237Theoretical
[M+Na]+426.342179Theoretical
[M+NH4]+421.386784Theoretical
[M-H]-402.345684Theoretical

Label Stability

Overall
Low risk
Calculation reliability
Medium, some information should be confirmed
  • Carbon-bound deuterium is evaluated by local chemical environment; isotope effects should still be checked experimentally.

Internal Standard Suitability

Rating
High
Chromatographic similarity
Possible isotope effect
Natural isotope overlap
Low
  • Exact mass separation is 3.01883 Da; MS channel separation should be verified in the final method.
  • The unlabeled parent mass was derived from the isotope structure because a curated parent structure was not matched.
  • Overall suitability: High.

Recommended Applications

LC-MS/MS Quantitative Internal Standard
Recommended

LC-MS/MS Quantitative Internal Standard is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

Isotope Dilution Mass Spectrometry
Recommended

Isotope Dilution Mass Spectrometry is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

GC-MS Internal Standard
Possible

GC-MS Internal Standard is classified as Possible based on isotope mapping, mass separation, and label-stability rules.

Bioanalytical Method Development
Recommended

Bioanalytical Method Development is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

AI Interpretation

This analysis is based on isotope-aware structure data. The compound contains D3, with an exact mass shift of 3.01883 Da. Label stability is assessed as Low risk, and internal-standard suitability is High. These results support analytical method development and require experimental validation.

AI-assisted analytical guidance is intended for method-development support. Actual isotope stability, chromatographic behavior, fragmentation and MRM transitions should be experimentally validated.