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R-10033

L-Alanine (13C3)

Stable isotope standard for analytical research and method development.

Module Type
Stable Isotope Standards
Category
Metabolites
CAS
100108-77-8
Unlabeled CAS
56-41-7
PubChem CID
16213446
Molecular Formula
[13C]3H7NO2
Molecular Weight
92.072
AI Isotope Property & Application AnalysisShow

Isotope Summary

Labels
13C3
Labeled atoms
3
Isotope positions
Confirmed in structure
Calculation reliability
High, based on explicit isotope structure

Mass & MS Parameters

Unlabeled exact mass
89.047678 Da
Labeled exact mass
92.057743 Da
Exact mass shift
3.010065 Da
Nominal mass shift
3
Ionm/zStatus
[M+H]+93.065019Theoretical
[M+Na]+115.046961Theoretical
[M+NH4]+110.091566Theoretical
[M-H]-91.050467Theoretical

Label Stability

Overall
Low risk
Calculation reliability
Medium, some information should be confirmed
  • Skeleton-bound 13C/15N labels are generally non-exchangeable under normal analytical handling.

Internal Standard Suitability

Rating
High
Chromatographic similarity
Expected high similarity
Natural isotope overlap
Low
  • Exact mass separation is 3.010065 Da; MS channel separation should be verified in the final method.
  • The unlabeled parent mass was derived from the isotope structure because a curated parent structure was not matched.
  • Overall suitability: High.

Recommended Applications

LC-MS/MS Quantitative Internal Standard
Recommended

LC-MS/MS Quantitative Internal Standard is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

Isotope Dilution Mass Spectrometry
Recommended

Isotope Dilution Mass Spectrometry is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

Metabolic Tracing
Possible

Metabolic Tracing is classified as Possible based on isotope mapping, mass separation, and label-stability rules.

Bioanalytical Method Development
Recommended

Bioanalytical Method Development is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

AI Interpretation

This analysis is based on isotope-aware structure data. The compound contains 13C3, with an exact mass shift of 3.010065 Da. Label stability is assessed as Low risk, and internal-standard suitability is High. These results support analytical method development and require experimental validation.

AI-assisted analytical guidance is intended for method-development support. Actual isotope stability, chromatographic behavior, fragmentation and MRM transitions should be experimentally validated.