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R-10013

Vitamin B2 (13C4, 15N2)

Stable isotope standard for analytical research and method development.

Module Type
Stable Isotope Standards
Category
Metabolites
CAS
1217461-14-7
Unlabeled CAS
83-88-5
PubChem CID
71310809
Molecular Formula
C13[13C]4H20N2[15N]2O6
Molecular Weight
382.32
AI Isotope Property & Application AnalysisShow

Isotope Summary

Labels
13C4, 15N2
Labeled atoms
6
Isotope positions
Confirmed in structure
Calculation reliability
High, based on explicit isotope structure

Mass & MS Parameters

Unlabeled exact mass
376.138284 Da
Labeled exact mass
382.145774 Da
Exact mass shift
6.007489 Da
Nominal mass shift
6
Ionm/zStatus
[M+H]+383.15305Theoretical
[M+Na]+405.134992Theoretical
[M+NH4]+400.179597Theoretical
[M-H]-381.138497Theoretical

Label Stability

Overall
Low risk
Calculation reliability
Medium, some information should be confirmed
  • Skeleton-bound 13C/15N labels are generally non-exchangeable under normal analytical handling.

Internal Standard Suitability

Rating
High
Chromatographic similarity
Expected high similarity
Natural isotope overlap
Low
  • Exact mass separation is 6.007489 Da; MS channel separation should be verified in the final method.
  • The unlabeled parent mass was derived from the isotope structure because a curated parent structure was not matched.
  • Overall suitability: High.

Recommended Applications

LC-MS/MS Quantitative Internal Standard
Recommended

LC-MS/MS Quantitative Internal Standard is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

Isotope Dilution Mass Spectrometry
Recommended

Isotope Dilution Mass Spectrometry is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

Metabolic Tracing
Possible

Metabolic Tracing is classified as Possible based on isotope mapping, mass separation, and label-stability rules.

Bioanalytical Method Development
Recommended

Bioanalytical Method Development is classified as Recommended based on isotope mapping, mass separation, and label-stability rules.

AI Interpretation

This analysis is based on isotope-aware structure data. The compound contains 13C4, 15N2, with an exact mass shift of 6.007489 Da. Label stability is assessed as Low risk, and internal-standard suitability is High. These results support analytical method development and require experimental validation.

AI-assisted analytical guidance is intended for method-development support. Actual isotope stability, chromatographic behavior, fragmentation and MRM transitions should be experimentally validated.